Zrinka TamburaΕ‘ev
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Zrinka TamburaΕ‘ev was a Croatian scientist known for her work in the development of antibiotics such as oxytetracycline and azithromycin.
Contents
β’ Early life
β’ Career
β’ Patents
β’ References
β’ External links
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Early life
TamburaΕ‘ev was born in Sisak, Kingdom of Yugoslavia, in 1921. She graduated in 1948 from the Chemical-Technological Department of the Technical Faculty in Zagreb and earned her doctorate in 1965.cite-ref-4-1-0[1]
Career
She joined the research institute of the pharmaceutical company PLIVA in 1957,cite-ref-4-1-1[1] where she made several discoveries and patents in departments of microbiology, biochemistry, and biotechnology. While at PLIVA she led the group for semisynthetic macrolides from 1972 to 1974, and in 1974 she was named the head of the natural products department.cite-ref-3-2-0[2]
In the mid-1960s, she worked with Slobodan ΔokiΔ on erythromycin A derivatives and on sulfonamide derivatives of erythromycylamine, with the idea of combining the properties of erythromycin and sulfonamides. She began work on the synthesis of individual phases for the preparation of azithromycin, and the results of this research challenged the previous understanding of the macrocyclic ring of erythromycin as the bearer of the antibacterial activity of macrolides. In 1974 her collaboration with Slobodan ΔokiΔ, Gabrijela Kobrehel, and Gorjana Lazarevski led to the development of azithromycin, an erythromycin derivative later established in the American market as Zithromax.cite-ref-0-3-0[3]cite-ref-4[4]
She devised a method for isolating the antibiotic oxytetracycline in its industrial production and dealt with the chemical transformations of tetracycline order antibiotics and erythromycin. She is a co-author of patents that protected the preparation of oximes of erythromycin A and erythromycylamine, important intermediates in the synthesis of second-generation macrolide antibiotics (azithromycin, clarithromycin, roxithromycin, and dirithromycin).cite-ref-0-3-1[3]
Selected publications
β’ citerefdjoki-tambura-ev1967DjokiΔ, Slobodan; TamburaΕ‘ev, Zrinka (1967-01-01). "Erythromycin study: 9-Amino-3-0-cladinosyl-5-0-desosaminyl-6,11,12- tryhydroxy-2,4,6,8,10,12-hexamethylpentadecane-13-olide". Tetrahedron Letters. 8 (17): 1645β1647. doi:10.1016/S0040-4039(00)70331-5. ISSN 0040-4039. PMID 6047192.
β’ citerefdjoki-tambura-ev1967DjokiΔ, Slobodan; TamburaΕ‘ev, Zrinka (1967-01-01). "Erythromycin study: 9-Amino-3-0-cladinosyl-5-0-desosaminyl-6,11,12- tryhydroxy-2,4,6,8,10,12-hexamethylpentadecane-13-olide". Tetrahedron Letters. 8 (17): 1645β1647. doi:10.1016/S0040-4039(00)70331-5. ISSN 0040-4039. PMID 6047192.
β’ citerefkobreheltambura-evdjoki-1977Kobrehel, Gabrijela; TamburaΕ‘ev, Zrinka; DjokiΔ, Slobodan (1977-03-21). "Erythromycin series: IV. Thin-layer chromatography of erythromycin, erythromycin oxime, erythromycylamine and their acyl derivatives". Journal of Chromatography A. 133 (2): 415β419. doi:10.1016/S0021-9673(00)83508-6. ISSN 0021-9673. PMID 838822.
β’ citereflazarevskitamburas-evdjoki-1977Lazarevski, Tomislav; TamburasΜev, Zrinka; DjokiΔ, Slobodan (1977-02-11). "Erythromycin series: V. Quantitative analysis of cladinose and methylcladinoside by densitometry of thin-layer chromatograms". Journal of Chromatography A. 132 (2): 309β313. doi:10.1016/S0021-9673(00)89305-X. ISSN 0021-9673. PMID 833239.
β’ citerefdjoki-kobrehellazarevskilopotar1986DjokiΔ, Slobodan; Kobrehel, Gabrijela; Lazarevski, Gorjana; Lopotar, Nevenka; TamburaΕ‘ev, Zrinka; Kamenar, Boris; Nagl, Ante; VickoviΔ, Ivan (1986-01-01). "Erythromycin series. Part 11. Ring expansion of erythromycin A oxime by the Beckmann rearrangement". Journal of the Chemical Society, Perkin Transactions 1: 1881β1890. doi:10.1039/P19860001881. ISSN 1364-5463.
Honors and awards
Following the discovery of azithromycin, she became the recipient of the City of Zagreb Awardcite-ref-1-5-1[5] for 1959, the PLIVA Award for 1996,cite-ref-3-2-1[2] and the Croatian Chamber of Economy's Golden Marten Award for Lifetime Achievement for 1998.cite-ref-0-3-2[3]cite-ref-7[7] In 1998 she also received the Nagrade HAZU-a.cite-ref-0-3-3[3]
Patents
Zrinka Tamburasev has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).cite-ref-8[8]
| 11-Aza-10-deoxo-10-dihydroerythromycin⦠| Patent number : 4328334 Abstract: 11-az⦠|
|---|---|
| 4-Dedimethylamino-4-arylsulfonamido-5a,⦠| Patent number: 4160783 Abstract: Novel⦠|
| N-(Benzenesulfonyl)-erythromycylamine d⦠| Patent number: 3983103 Abstract: The ne⦠|
| Manufacture of N-(benzenesulfonyl)-5-O-⦠| Patent number: 3939144 Abstract: N-(4-R⦠|
References
cite-note-3-22. β citerefkovcevic2003Kovcevic, Kruno (2003). "In memoriam β Dr. Zrinka TamburaΕ‘ev". Journal of Chemists and Chemical Engineers of Croatia. 52 (6): 287.
cite-note-0-33. β citerefmikul-i-2020MikulΔiΔ, V. GodiniΔ (2020-03-11). "TamburaΕ‘ev, Zrinka | Hrvatska tehniΔka enciklopedija" (in Croatian). Retrieved 2023-12-04.
cite-note-44. β citerefdom-nguez2023DomΓnguez, Oriol GΓΌell (9 Dec 2023). "Las resistencias bacterianas amenazan a la azitromicina, uno de los fΓ‘rmacos mΓ‘s vendidos del mundo". EL PAΓS (Mexico Edition); Miami. ].
cite-note-1-55. β "Preminula Zrinka TamburaΕ‘ev, jedna od izumitelja Sumameda". www.index.hr (in Croatian). April 25, 2003. Retrieved 2023-12-04.
cite-note-2-66. β "TamburaΕ‘ev, Zrinka". www.enciklopedija.hr. Retrieved 2023-12-04.
cite-note-77. β citerefan-elkovi-2023AnΔelkoviΔ, Katarina (2023-03-07). "Antibiotics, Vegeta, Lasers: Meet the Legendary Croatian Female Scientists". Total Croatia. Retrieved 2023-12-04.
cite-note-88. β citerefaffairs-opaAffairs (OPA), USPTO Office of Public. "United States Patent and Trademark Office". www.uspto.gov. Retrieved 2023-12-04.
External links